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Cardiac Disease Modeling

This imaging possibility provides us with non invasive in-vivo parameters of the mouse heart. The most relevant parameters for our experimental investigations are the left ventricular wall thickness (Fractional shortening, FS) and the endsystolic and –diastolic chamber diameter. Our ultrasound employs a very precise technique for generating reproducable images with a range of 0.1 mm (Vevo Imaging System der Firma VisualSonics). This are important conditions to image the mouse heart with a wall thickness of 1 mm and a heart rate of 600 bts/min.